DenzelWash
Well-known member
We had 16m AUD from Trade Debtors open from FY21. There’s no way all of them were included in the September 4cQuarterly July sept 21 cash receipts:. 17,785,000 AUD

We had 16m AUD from Trade Debtors open from FY21. There’s no way all of them were included in the September 4cQuarterly July sept 21 cash receipts:. 17,785,000 AUD
@DenzelWash you prompted me to think about the global ambassadors and social media strategy.@Frogster Good point. PW actually pointed towards at the AGM to something like this…starting from minute 48
I could argue good results in the first 3 XP patients may be meaningful.Just relistened to the AGM again to confirm PW's statement linking XP trial results with OTC launch and here is the direct quote regarding the 'when' for the launch of the OTCs:
"The moment that you are generating the first meaningful results in XP, it makes absolutely perfect sense to introduce your products into these populations". Populations here means the OTC market, not the XP population.
So, the statement on 'meaningful' results is subjective, but seeing all the n=6 results will be the absolute minimum.
And of course that can be correct too. If they're wanting to show that afamelanotide can affect the MED (minimal erythema dose) then they don't need a tiny sample of XP patients (which are not comparable to the general population any way) - they have a truckload of this data already from earlier stage development trials. So, it is only about DNA repair in my eyes.I could argue good results in the first 3 XP patients may be meaningful.
XP-A? Another variant that could possibly be treated?And of course that can be correct too. If they're wanting to show that afamelanotide can affect the MED (minimal erythema dose) then they don't need a tiny sample of XP patients (which are not comparable to the general population any way) - they have a truckload of this data already from earlier stage development trials. So, it is only about DNA repair in my eyes.
Here's a bit of positive reading on why we should be expecting some positive results here.
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Melanocyte-Stimulating Hormone Directly Enhances UV-Induced DNA Repair in Keratinocytes by a Xeroderma Pigmentosum Group A–Dependent Mechanism
Melanocyte-stimulating hormone (MSH) reduces UV-induced DNA damage through the induction of pigmentation. In this study, we provide evidence that MSH also enhances DNA repair in skin keratinocytes by modulating the function of DNA repair molecules. Intracutaneous injection of MSH prevented...cancerres.aacrjournals.org