Scientific Gut bacteria and the microbiome influencing neurodegenerative disorders

macgyver

Well-known member
The following article talks about ‘bad bacteria’ causing toxic proteins to build up in a worm species and eventually affect their mobility among other symptoms. Patients with Alzhiemers and Parkinson’s are known to be deficient in ‘good’ bacteria according to the researchers so this study may increase understanding of how ‘bad bacteria’ may be influencing the development of these neurodegenerative disorders
 
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macgyver

Well-known member
"Deletion of desacetyl-α-MSH and α-MSH from the female mice resulted in loss of protection from diet induced obesity and a failure to reduce villus length on exposure to the chronic HF diet. These anatomical changes were accompanied by changes in the gut microbiota and fecal SCFA concentrations. We conclude that these structural changes to the gut contributed to the observed increase in female body weight that occurred in the absence of an appreciable increase in food intake or caloric consumption."

My takeaway from this is if you had an elevated level of a-msh above what the body normally produces it would not only have a positive effect on regulating obesity resulting from a chronic high fat diet, but it would as a positive side effect lead to better regulation of the microbiome simply because the a-msh has mitigated the impact of chronic high fat reducing the 'richness' of gut bacteria.

Fascinating to read through the scientific literature and understand the causal relationships between the body's systems and how a-msh plays an overarching role in these.


 
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macgyver

Well-known member
The following is a drug being developed by Cortexyme Inc in San Fransisco. Interesting to note the bacteria causing Gingervitis has been linked to AD. It pays to brush your teeth properly, or over-indulge in the use of Listerine...

"Atuzaginstat (COR388) is a bacterial protease inhibitor. It targets the infectious pathogen Porphyromonas gingivalis gingipains, a bacterium purportedly linked to periodontal disease and AD and linked to the production of amyloid beta (Aβ) in preclinical and clinical models. P gingivalis gingipains is found in the brain tissue and cerebral spinal fluid of people with AD. Atuzaginstat purportedly could be the first disease- modifying treatment to reduce brain infection, block Aβproduction, reduce neuroinflammation, and impart neuroprotection for patients with mild to moderate AD."


"A new study from 2018 found compelling evidence that gingivitis bacteria may be linked to Alzheimer's disease. Scientists agree that more research is needed to prove a cause and effect link.[7] "Studies have also found that the bacteria P. gingivalis – which are responsible for many forms of gum disease – can migrate from the mouth to the brain in mice. And on entry to the brain, P. gingivalis can reproduce all of the characteristic features of Alzheimer’s disease."


Incredible to think a-msh may play a role in mitigating toxins these bad bacteria create that cause an array of afflictions plaguing the human race and bringing untold misery. Rather than a-msh being a therapeutic treatment after the fact, its better to think of the peptide as a preventative getting at the root cause of many problems. Take a spoonful of a-msh in the morning or before you go to bed...
 
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Johnny H

Well-known member
My takeaway from this is if you had an elevated level of a-msh above what the body normally produces it would not only have a positive effect on regulating obesity resulting from a chronic high fat diet, but it would as a positive side effect lead to better regulation of the microbiome simply because the a-msh has mitigated the impact of chronic high fat reducing the 'richness' of gut bacteria.
I certainly hope that Clinuvel is collecting this data as part of PASS.
 

macgyver

Well-known member
It would be a dream if they were collecting comprehensive data of this nature for future use. But I’m not overly confident they were that foresighted way back when. As far as gut bacteria is concerned at any rate😆
 
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