From my very limited understanding, MT1 differs from MT2 in that it doesn’t have a ‘conformational’ structure like MT2, it tends to break off into pieces which is why it mostly manifests in secondary effects in the body. Whereas MT2 has a cyclised (‘conformational’) structure enabling it to maintain its integrity and hold together longer as it gets absorbed. So I guess when it comes to the BBB, it stays together long enough to crossover and have a direct impact in the brain? So to answer the second part of your question I would say yes if you’re talking about the brain as more melanocortin is getting across the BBB, other systemic inflammation I'm not so sure. It would end up having a similar effect I'd imagine.How is MT1 different from MT2 in this regard?
And does this equate to MT2 being a better anti inflammatory for systemic inflammation diseases in regards to a low dosage anti-aging regimen?