We know afamelanotide doesn't permeate the BBB well. However regarding stroke, acting on the blood vessels itself to prevent inflammation and strengthening the BBB after a serious event is likely to improve the outlook for the patient. Melanotan-II is cyclised so it will permeate the BBB more so, but the only other molecules in Clinuvel's stable are skin related (CUV9900, phimelanotide, parvysmelanotide, VRX001). The research done by Daniela Guiliani (as recently posted by Uhoh and @investek here) discovered intense inducement of neuogenesis from a-msh, in addition to what it already does when acting on the blood vessels and facilitating the automatic process of neurogenesis following a stroke.
I'm not clear on the science, but I wonder if a dissolvable implant of a-msh inserted into the penumbra closest to the necrotic core might stimulate intense neurogenesis essentially giving that process a supercharged effect and salvaging more of the penumbra than just acting on the blood vessels alone. Initially I thought Mr McEvoy might've been hired to design a device to insert Enfance, but that seems utterly basic for someone of his expertise. Looking forward to seeing what comes out of this.
This lady talks about delivering drugs via a catheter system directly into brain tissue, of which she mentions at one point delivering drugs into the penumbra of a glioblastoma. This procedure has been used in 46 Parkinson's disease patients. The procedure device/system shown here doesn't look particularly 'elegant' but if it works...
I'm of the opinion now that this is a feasible proposition to insert Afamelanotide directly into the penumbra. Neurosurgery methods concerning catheters are widespread, and having watched a few Medtronic videos (Fran McEvoy's former employer) it seems a straightforward process (animations can turn the observer into a neurosurgeon overnight). The only concerns would be the composition of the implant itself and the reaction of the brain to the foreign implant within its tissue.