Scientific The role of the blood-cerebral spinal fluid barrier in neurological disorders


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An interesting development this morning with Sharelooker’s great find about a potential new drug/delivery system from Clinuvel, and kudos to Alexius for finding a possible key to unlocking the meaning of this development. As it stands it’s far too early to see what this development is about until an announcement is made, but nonetheless I think it’s important to pursue leads to wherever they end for good or ill, and to post relevant information here to further the collective knowledge of the group.

The cerebral spinal fluid (CSF) is something that hasn’t been elaborated on here before, although in the Fran McEvoy thread I touched on drug delivery either via epidural or intrathecally. I wasn’t aware of the importance of the role the CSF plays in neuroinflammation and neurodegeneration, thinking it was just a marvel of nature to engineer a ‘floating repository’ for the brain so to speak. But the following paper lays out the functions of the CSF and it’s role in related ailments including Alzheimer’s disease and multiple sclerosis, in particular it mentions the disfunction of the CSF as a characteristic of the aging/injured brain.

“Derangement of the functions of CSF circulation may play a key role in the development of a wide range of CNS pathologies, including neurodegenerative diseases such as Alzheimer’s disease (AD), neuroinflammatory conditions such as multiple sclerosis (MS) and neurovascular conditions such as cerebral ischemia, traumatic brain injury (TBI) and subarachnoid hemorrhage.”
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